Eurofins Biomnis code

PT12

Synonyms

• F 1+2
• Prothrombin - fragment 1+2

Specialty

Haematology

Clinical significance

The conversion of prothrombin into active thrombin entails the production of cleavage fragments which can be assayed to give a measure of the overall amount of thrombin being generated. This test is useful in the diagnosis of disorders involving overactive coagulation mechanisms and thromboembolism. High readings are obtained in patients with thrombosis, pulmonary embolism, diffuse intravascular coagulation, multiple trauma and septicemia. The levels of these fragments may also be increased in patients with Protein C or Protein S deficiency.The level of these fragments 1 and 2 can be significantly reduced in patients on anticoagulant therapy.

Preanalytics

• 1 mL :
• Citrated Plasma
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : Yes

Further information

Reject any samples where sample collection was difficult and where onset of coagulation could have occurred
1 individual aliquot for this analysis.
It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.

Methodology

Enzyme-immunoassay

Turnaround time

1 month