Eurofins Biomnis code

RUBEO

Clinic significance

A usually benign disease of children which causes skin eruption and lymphadenopathy. It breaks out sporadically with major epidemics once every few years. If a pregnant women becomes infected in the first trimester, in utero infection may occur and this can result in the death of the embryo or severe developmental abnormalities affecting the heart, the inner ear and the eye. If infection is later in the term, the development of the fetus may be retarded or it may have hematological and bone abnormalities which resolve spontaneously in many cases. Alternatively, the child may be born apparently healthy and the consequences of the antenatal infection only become apparent later with heart disease, deafness or, fairly rarely, psychomotor retardation. Antenatal diagnosis of transplacental infection involves the detection of viral RNA (by RT-PCR) in amniotic fluid with, if necessary, an immunocapture assay for specific IgM antibodies in blood drawn from the umbilical vein (during an ultrasound examination). In general, diagnosis depends on the observation of seroconversion and the detection of specific IgM which appear two weeks after infection and disappear within 3 to 8 weeks. The presence of specific IgM in cord blood suggests that congenital infection has occurred. IgG antibodies persist and are protective.

Prenalytics

• 1 mL
• Serum
• Refrigerated

Methodology

EIA

Turnaround time

4 days