Eurofins Biomnis code

TBE

Synonyms

• Arbovirus
• ERVE serology
• MEVE
• RSSE
• TBE virus - serology
• Tick Born Encephalitis
• Tick-born encephalitis - TBE
• [To be translated]

Specialty

Infectious

Clinical significance

Infection with the tick-borne encephalitis virus occurs mainly through tick bites and food. Infection begins with a flu-like syndrome lasting around a week, which may go unnoticed, and in 1/3 of patients the infection continues with an improvement followed by a neurological phase associating headaches, pronounced asthenia and meningeal signs. Neurological sequelae are observed in 25 to 65% of cases. Diagnosis is based on molecular biology in the blood during the first phase of infection (up to 5 days after the onset of symptoms). After the viremic phase, diagnosis is based on serology. Antibodies appear 2 to 3 weeks after infection. IgM antibodies persist for several months after infection, while IgG antibodies persist for life, conferring protective immunity. Serological cross-reactions are observed between the different species of the Flavivirus genus (Dengue, Zika, West-Nile, Yellow Fever, etc.), so the interpretation of a positive serology must take into account the geographical area where the patient has been exposed (co-circulation of other Flaviviruses?), the patient's history and the patient's vaccination status against TBE. Confirmation by seroneutralisation (carried out by the National Reference Centre) on a late serum makes it possible to diagnose the species.

Preanalytics

• 1 mL :
• serum
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

Enclose the specific clinical information form (R35-INTGB : Infectiology)

Documents to download

• Specific clinical information form (R35-INTGB)

Methodology

Chemiluminescence

Turnaround time

8 days