Eurofins Biomnis code

TGLU

Synonyms

• Anti gluten IgA antibodies
• Human tissue transglutaminase - IgA - anti-antibodies
• TTG - IgA - anti-antibodies

Specialty

Immunology

Clinical significance

In 1997, it was demonstrated that the antigenic target of anti-endomysium antibodies is in fact tissue transglutaminase (tTG). This made it possible to perform ELISA tests. The correlation between anti-endomysium and ant-transglutaminase antibodies is of the order of 98% for coeliac disease diagnosis. The test performed uses a more specific human recombinant transglutaminase.

Preanalytics

• 1 x 1 mL :
• serum (do not use 10 mL tube)
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

During the assay of the IgA anti-transglutaminase antibodies, if there is an alarm causing us to suspect a deficit in total IgA, the assay of total IgA and the assay of anti-transglutaminase IgG antibodies will be carried out in order to make the diagnosis of coeliac disease.
For celiac disease diagnosis, results are valid only if patient is under a ¿normal¿ diet (including gluten) and if there is no evidence of IgA deficiency

Methodology

Fluorescent enzyme-immunoassay

Turnaround time

3 days