Eurofins Biomnis code

THSD7

Synonyms

• anti- protein 7A of thrombospondine antibodies

Specialty

Immunology

Clinical significance

Idiopathic extra-membranous glomerulonephritis is one of the main causes of glomerular nephropathy in adults, and can lead to severe or terminal renal failure. The etiology and pathophysiology of this disease are still poorly understood, but is characterized by the presence of immune deposits at the level of the glomerular basement membrane, consisting of circulating autoantibodies directed against an antigen present on the surface of the epithelial cells essential for glomerular filtration : the podocytes. More than 70% of adult patients with idiopathic extra-membranous glomerulonephritis have circulating autoantibodies of the IgG4 type that are directed against the phospholipase A2 receptor (PLA2R) present on the surface of podocytes. The prevalence of anti-THSD7A ranges from 2.5% to 14%. In rare cases, autoantibodies against PLA2R and THSD7A can also be found together.

Preanalytics

• 1 x 1 mL :
• Sérum
•   Refrigerated

• A tube specifically for this analysis : No

Further information

1 individual aliquot for this analysis.

Methodology

Immunofluorescence

Turnaround time

2 weeks

Caption