Eurofins Biomnis code

TOB

Synonyms

• Nebcine®
• Tobi®
• Tobradax®
• Tobrex®

Specialty

Analytical Chemistry

Clinical significance

A bactericidal aminoglycoside antibiotic which inhibits bacterial protein synthesis by binding to ribosomes. Its natural anti-bacterial spectrum includes Gram-negative and Gram-positive bacilli, and staphylococci. Must be administered parenterally (IM or IV). Eliminated as the active substance via the kidneys with a half-life = 2 to 4 hours in adults and 3 to 6 hours in new-borns and babies. It can cause renal and cochleovestibular toxicity at plasma concentrations well above the normal. Its therapeutic index is relatively low so monitoring residual levels and peak plasma concentrations is important. Residual levels show whether or not there is any accumulation of the drug in the kidneys or the inner ear. The peak concentration immediately after administration can be used to assess the bactericidal activity of the dose administered.

Preanalytics

• 1 mL :
• serum
•   FROZEN before sending

• A tube specifically for this analysis : Yes

Further information

Enclose the specific clinical information form (R18-INTGB : Infectious agents)
1 specific aliquot for this analysis
Residual level = before injection; Peak = 30 min after end of infusion or 1 hr after IM injection

Documents to download

• Specific clinical information form (R18-INTGB)

Methodology

PETINIA immunoturbidimetric technique

Turnaround time

1 day