Eurofins Biomnis code

USTEK

Synonyms

• Anticorps anti-Ustekinumab
• Pyzchiva
• Stelara®
• Steqeyma
• Ustekinumab
• Uzpruvo
• Wezenla

Specialty

Immunology

Clinical significance

Ustekinumab is a fully human IgG1¿ monoclonal antibody that specifically binds to the p40 protein subunit common to human interleukin (IL)-12 and IL-23 cytokines. Abnormal regulation of IL-12 and IL-23 has been associated with immune-mediated diseases such as psoriasis, psoriatic arthritis, and Crohn's disease. Antibodies to ustekinumab may develop during treatment with ustekinumab, and most are neutralising. The formation of antibodies against ustekinumab is associated with increased clearance of ustekinumab and decreased efficacy of ustekinumab, except in patients with Crohn's disease, in whom no decrease in efficacy has been observed. Testing for ustekinumab and anti-ustekinumab antibodies is recommended in cases of loss of clinical response to biotherapies, drug optimisation, change of drug class, addition of an immunosuppressant, dose reduction or discontinuation of treatment.

Preanalytics

• 1 mL :
• serum
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : No

Further information

Please attach the specific clinical information sheet (R46 : Anti-TNF)

Documents to download

• Specific

Methodology

Enzyme-immunoassay

Turnaround time

15 days