Eurofins Biomnis code

VANC

Synonyms

• Vancocin®

Clinic significance

A bactericidal glycopeptide antibiotic which is often co-prescribed with an aminoglycoside and which is not subject to crossed resistance with any other antibacterial. It acts by inhibiting cell wall synthesis in Gram-positive bacilli and its antibacterial spectrum of activity covers the staphylococci (including methicillin-resistant strains), the streptococci, the enterococci, the pneumococci and Gram-positive bacilli and anaerobes.
It is administered IV to treat systemic infections. It is eliminated in the urine rapidly and unmetabolized (i.e. in its active form). Average half-life = 6 hours in adults (can vary between 5 and 12 hours). Toxicity (which mainly affects the kidneys and the cochlea) is dose-dependent and is most commonly seen following massive overdosage.
Measuring the residual level is useful for detecting accumulation in the kidneys or the inner ear.
The post-injection peak concentration measurement is used to check the bactericidal efficacy of the administered dose.
If the drug is being administered by continuous perfusion, only one blood sample needs to be taken. The serum concentration should remain between 20 and 35 mg/l in adults and between 20 and 25 mg/l in children.

Prenalytics

• 1 mL
• Serum
• FROZEN before sending

Further information

• Sampling time: residual level = before IV injection; post-injection peak = 45 to 60 min after end of IV infusion
• Enclose the specific clinical information form (R18-INTGB : Infectious agents)
• 1 specific aliquot for this analysis

Documents to download

• Specific clinical information form (R18-INTGB)

Methodology

PETINIA immunoturbidimetric technique

Turnaround time

2 days