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Tropheryma whipplei - direct diagnosis - PCR

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Eurofins Biomnis code



  • Whipple's disease
  • Whipple - disease

Clinic significance

Tropheryma whippelii is a Gram-positive, non cultivable bacteria supposed to be responsible for Whipple disease. This chronic affection combines digestive malabsorption with respiratory, cardiac, neurologic and ocular complications. Serology is not yet available. Demonstration of the bacterial genome is the only way to perform diagnosis, which should be reached as soon as possible to allow for adapted antibiotherapy.


  • BAL, Plasma or EDTA whole blood, serum, biopsy, stool, puncture fluid, saliva, 0.5 mL CSF (minimum), urine
  • Refrigerated

Further information

  • Swab samples require the use of a virus transport medium supplied upon request M4RT (REMEL)
  • Biopsies should be placed as they are, in a dry tube .
  • All histological fixatives are forbidden.
  • The use of the S14UK transport bag is Mandatory.
  • other biological samples must not be diluted, to be sent in a plain tube

Specific equipment available

K1: Virus screening kit by culture or PCR

Documents to download


Real-time PCR

Turnaround time

3 days

Pathologist(s) in charge
Biomnis Lyon
Dr Véronique JACOMO
Dr Xavier NAUDOT
+334 72 80 47 43
+334 72 80 73 01

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