Eurofins Biomnis code

MOHC1

Synonyms

• Acquired karyotypes
• Conventional acquired cytogenetics

Specialty

Oncology- haematology

Clinical significance

Indications: - Myeloid neoplasia: Myeloproliferative neoplasia (MPN): CML, CNL, PV, MFP, TE Mastocytosis Myeloid/lymphoid neoplasia with eosinophilia Myelodysplastic/myeloproliferative neoplasia: CML, CMML, JMML Myelodysplastic syndromes - Mature lymphoid neoplasia: Mature B-cell neoplasia: CLL, B-cell prolymphocytic leukemia, MZL, Hairy cell leukemia, Waldenström's macroglobulinemia, lymphoplasmacytic lymphoma, follicular lymphoma, GCPL, Burkitt's, high-grade B-cell lymphoma Monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma Mature T- and NK-cell neoplasia: prolymphocytic T-cell leukemia, LGL, hepatosplenic T-cell lymphoma, Sezary syndrome/mycosis fungoides, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma - Acute leukemias: Acute myeloid leukemias and associated neoplasia: AML with recurrent genetic abnormalities, AML with abnormalities related to myelodysplasias, treatment-related myeloid neoplasias, AML NOS Acute leukemias of ambiguous lineage B-precursor lymphoblastic lymphoma/leukemia T-precursor lymphoblastic leukemia/lymphoma Chimerism

Preanalytics

• 5 mL Heparinized whole blood, 2 mL Bone marrow (lithium heparin), lymph nodes
•   Ambient temperature

• A tube specifically for this analysis : No

Further information

Bone marrow: 1 heparinised syringe or medullary puncture transferred into a lithium heparinate tube ,Lymph node: sterile bottle
Cytogenetic study in the context of Myeloma: must be performed on bone marrow (not on peripheral blood). Exception: Plasma cell leukaemia: peripheral blood or bone marrow.
Attach:
- the clinical and therapeutic data
- the results of the FBC - Platelets
- the bone marrow report
- the immunophenotyping report

Specific equipment available

• S9L: Envelopes yellow for karyotypes LYON

Documents to download

• Specific request form B8-INTGB
• DS2-INTGB - Pathological diagnosis and follow up of patients with Chronic Myeloid Neoplasms
• DS3 -INTGB - Acute leukemia
• DS62- Mature lymphoid noeplasm

Methodology

Conventional cytogenetics: Culture + chromosome analysis

Turnaround time

Time according to indication: - AL: 1 week - CMN and MDS: 2 weeks - LPD and myeloma: 3 weeks